I have found uptiding very successful round here, including a 6lb place in the harbour. I used to use mono up until a couple of years ago and had no problems at all. Then I changed to the new 'miracle' braid but after a couple of years I am going to go back to mono for uptiding. I can't put my finger on exactly what I don't like with braid but the thicker diameter of mono seems to suit the drag profile of the line in a differant way to the thinner braid, making bite indcation far more posative. This is my take but no doubt there will be other opinions too.
Mad Mike