Just a bit of advice from my Dad several years ago, "Put another jumper on!"
Your boiler will be heating up the pipes all the way up to the radiator which is turned off, so really the rad might was well be turned on.
The water will flow around the system better as well, pushing out any air bubbles which are likely to be in the system.
My advice would be put everything on full for a bit, wait for all of the gurgling and clunking noises to stop (!), go round and bleed the air out of the radiators, then turn down (not off) all of the TRV's so that it the house is just warm (not roasting)- this will probably take a bit of trial and error. This should be the most efficient way to keep your abode habitable.
It is more efficient to heat the house up and then keep it warm than it is to heat it up, let it cool, heat it up, let it cool, or to try to heat up only parts of it (beacuse the cold parts will suck the heat out of the warm parts and the rads in the warm parts will be fighting against it all the time.
Hope this helps.